Literatur Review: Kajian Tanaman Obat Untuk Mengatasi Penyakit Sistem Saraf Pusat di Indonesia

  • Marina Azzahra Nasution Universitas Negeri Medan
  • Novayanti Gultom Universitas Negeri Medan
  • Melva Silitonga Universitas Negeri Medan
Keywords: central nervous system, medicinal plants, central nervous system disorders

Abstract

Various health disorders related to the central nervous system have a major impact on humans. Various health disorders related to the central nervous system are Parkinson's, Alzheimer's, epilepsy, mental and anxiety disorders in the form of stress, depression. In the consumption of excessive drugs, of course, it will provide sustainable side effects or that the effect of dependence in its use. The utilization of medicinal plants used to overcome various diseases of the central nervous system is one of the alternatives used by the community both in the roots, stems, leaves and other plant parts. Based on the description above, this study aims to examine medicinal plants that are useful for central nervous system disorders such as stress, depression, Parkinson's disease, alzherzair and various other central nervous system disorders.The research method used in this study is an online search or literature study. Based on the results of the literature review, it can be concluded that medicinal plants that are useful for overcoming diseases of the central nervous system are Nutmeg Seeds (Myristica fragrans Houtt), Fennel Fruit (Foeniculum vulgare Mill.), Moringa Leaves (Moringa oleifera Lam.), Bacopa monnieri, Bacopa monnieri, and Bacopa monnieri. ), Bacopa monnieri, Centella asiatica, Curcuma longa, Cyperus rotundus, Morinda citrifolia, Withania somnifera , Amethyst Flower (Datura metel Linn), Turmeric Rhizome (Curcuma longa L), Ethanol extract of Senna spectabilis (DC), Essential Oil of Basil Leaves (Ocimum basilicum L).

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References

Abbasi-Maleki, S., & Maleki, S. G. (2021). Antidepressant-like effects of Foeniculum vulgare essential oil and potential involvement of dopaminergic and serotonergic systems on mice in the forced swim test. PharmaNutrition, 15(June 2020), 100241. https://doi.org/10.1016/j.phanu.2020.100241

Abdul, A., Wahyu Safitri, F., & Purbowati, R. (2020). Efek Pemberian Ekstrak Etanol Buah Adas (Foenicullum vulgare Mill.) terhadap Kadar Hormon Prolaktin Tikus Putih Betina Post Partum The Effect of Ethanol Extract of Fennel Fruit (Foenicullum vulgare Mill.) on Hormone Prolactin Levels of White Female Post P. Jurnal Farmasi Indonesia, 17(1), 5–6. http://journals.ums.ac.id/index.php/pharmacon

Adelina, R. (2013). Kajian Tanaman Obat Indonesia yang Berpotensi sebagaiAntidepresan. Jurnal Kefarmasian Indonesia, 3(1), 9–18.

Alfayat, M. P., & Wardhana, A. K. (2024). DETEKSI DINI ALZHEIMER PADA OTAK DENGAN KOMBINASI METODE. Jurnal Teknologi Informasi Dan Komunikasi, 19(1), 32–41. https://doi.org/https://doi.org/10.33005/scan.v19i1.4735

Bum, E. N., Nkantchoua, G. N., Njikam, N., Taiwe, G. S., Ngoupaye, G. ., Pelanken, M. M., Nanga, Maidawa, F., Rakotonirina, A., & Rakotonirina, S. V. (2010). Anticonvulsant and Sedative Activity of Leaves Senna spectabilis in Mice. INternational Journal of Pharmacology, 6(2), 123–128.

Carrera, S., Vara, J. S., & Strik, T. (2019). The external dimensions of EU migration and asylum policies in times of crisis. Constitutionalising the External Dimensions of EU Migration Policies in Times of Crisis: Legality, Rule of Law and Fundamental Rights Reconsidered, 1–19. https://doi.org/10.4337/9781788972482.00007

Dababneh, M. F., Derymedvid, L. V., Korang, L. A., Tsyvunin, V. V., Kalko, K. O., Yaremenko, M. S., & Boriak, L. I. (2021). The effect dealcoholized extract of acorus calamus leaves (Acorus calamus L.) on the behavior of animals under reserpin-induced depression. Pharmacologyonline, 1, 187–192.

Dar, N. J., Hamid, A., & Ahmad, M. (2015). Pharmacologic overview of Withania somnifera, the Indian Ginseng. Cellular and Molecular Life Sciences, 72(23), 4445–4460. https://doi.org/10.1007/s00018-015-2012-1

Dayalan, G., Ramasamy, K., Natarajan, M., Kathirvelu, P., Shanmugasundaram, J., & Sivaraman, S. (2022). Exploration of Central Nervous System Activities of Caryota Urens ethanolic Leaf Extract on Neurological Disorders in Experimental Animal Models. Journal of Pharmaceutical Negative Results, 13(3), 628–634. https://doi.org/10.47750/pnr.2022.13.03.092

Doyno, C. R., & White, C. M. (2021). Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank. Journal of Clinical Pharmacology, 61(S2), S114–S128. https://doi.org/10.1002/jcph.1922

Ekasari, W., Widyowati, R., Wahyuni, T. S., Suciati, Oktarina, R. D., Ardianto, C., Prameswari, E. S., Suri, W. A. A., Kurnia, A. I., Wirabuana, R. K., Angembani, V. M. A., & Sahu, R. K. (2023). Central nervous system depressant effect of ethanol extract of Senna spectabilis (DC.) H.S.Irwin & Barneby in mice. Journal of Pharmacy and Pharmacognosy Research, 11(6), 1072–1078. https://doi.org/10.56499/jppres23.1579_11.6.1072

Fitri, Y. A., Priambodo, D.-, & Lestari, K.-. (2018). FORMULASI TABLET DARI EKSTRAK BIJI PALA (Myristica fragrans Houtt.) BEBAS MIRISTISIN DAN SAFROL DENGAN METODE GRANULASI BASAH. Jurnal Sains Dan Teknologi Farmasi Indonesia, 5(2), 8–22. https://doi.org/10.58327/jstfi.v5i2.55

Hasanah, A., Khoerunnisa, A., Aisyah, S., Aeni, F. N., & Yuniarsih, N. (2022). Review artikel: Kajian Tanaman Herbal yang Digunakan untuk Penyakit Saraf melalui Sistem Penghantaran Obat Sistem Saraf Pusat. Jurnal Pendidikan Dan Konseling, 4(6), 12441–12447.

Hasanusi, I. N., Silalahi, P. Y., Bension, J. B., Huwae, L. B. S., Angkejaya, O. W., & Taihuttu, Y. M. J. (2020). EFEK PEMBERIAN EKSTRAK ETANOL BIJI PALA (Myristica fragrans Houtt) TERHADAP ANSIETAS MENCIT (Mus musculus). PAMERI: Pattimura Medical Review, 2(1), 36–46. https://doi.org/10.30598/pamerivol2issue1page36-46

Kalin, N. H. (2020). The critical relationship between anxiety and depression. American Journal of Psychiatry, 177(5), 365–367. https://doi.org/10.1176/appi.ajp.2020.20030305

Lestiyoningsih, D., Azhari, N. K., & Noviyanti, L. K. (2024). Hubungan Efikasi Diri Dengan Tingkat Depresi Pada Lansia Dengan Penderita Stroke Di Rsi Sultan Agung Semarang. Jurnal Fisioterapi Dan Ilmu Kesehatan Sisthana, 6(1), 15–22. https://doi.org/10.55606/jufdikes.v6i1.867

Lumintang, R. F., Wuisan, J., & Wowor, P. M. (2015). UJI EFEK ANALGESIK EKSTRAK KULIT BATANG POHON MATOA (Pometia pinnata) PADA MENCIT (Mus musculus). Jurnal E-Biomedik, 3(2), 3–8. https://doi.org/10.35790/ebm.3.2.2015.8620

Madziga, H. A., Sanni, S., & Sandabe, U. K. (2021). Study on Phytochemical and Elemental Analysis of Acalypha wilkesiana Leaf. Current Approaches in Science and Technology Research Vol. 10, 6(1), 96–101. https://doi.org/10.9734/bpi/castr/v10/10633d

Maheshwari, N. O., Khan, A., & Chopade, B. A. (2013). Rediscovering the medicinal properties of Datura sp .: A review. Journal of Medicinal Plants Research, 7(39), 2885–2897. https://doi.org/10.5897/JMPR11.1657

Merwanta, S., Pameswari, P., & Maria, O. (2019). Jurnal Akademi Farmasi Prayoga. Jurnal Akademi Farmasi Prayoga, 4(1), 42–55.

Mishra, S., & Palanivelu, K. (2008). The effect of curcumin ( turmeric ) on Alzheimer ’ s disease : An overview Introduction Curcumin and Alzheimer ’ s Disease Epidemiological Studies Curcumin as an Anti Inflammatory in Alzheimer ’ s Curcumin as an Anti-oxidant. Annals of Indian Academy of Neurology, 11(1), 13–19.

Neamati, A., Talebi, S., Hosseini, M., Hossein Boskabady, M., & Beheshti, F. (2015). Administration of Ethanolic Extract of Ocimum Basilicum Leaves Attenuates Depression like Behavior in the Rats Sensitized by Ovalbumin. Current Nutrition & Food Science, 12(1), 72–78. https://doi.org/10.2174/1573401311666151030213446

Nkamguie Nkantchoua, G. C., Kameni Njapdounke, J. S., Jules Fifen, J., Sotoing Taiwe, G., Josiane Ojong, L., Kavaye Kandeda, A., & Ngo Bum, E. (2018). Anticonvulsant effects of Senna spectabilis on seizures induced by chemicals and maximal electroshock. Journal of Ethnopharmacology, 212(October), 18–28. https://doi.org/10.1016/j.jep.2017.09.042

Pratiwi, I. N., Aligita, W., & Kaniawati, M. (2021). A study of antioxidant potential from herbal plants and the effects on Parkinson’s disease. Jurnal Ilmiah Farmasi, 17(1), 80–95. https://doi.org/10.31001/jfi.v14i2.370

Puspitasari, L. (2017). Ekstrak etanol daun pandan wangi (pandanus amaryllifolius r.) 10% menurunkan immobility time dan kadar kortisol tikus jantan galur wistar yang depresi. Intisari Sains Medis, 8(1), 24–30. https://doi.org/10.15562/ism.v8i1.107

Rahma, S. P., & Suzana, D. (2024). Uji Aktivitas Antidepresan Minyak Atsiri Daun Kemangi (Ocimum Basilicum L) Dengan Metode Open Field Test (Oft). Jurnal Farmasi Dan Farmakoinformatika, 2(1), 9–22. https://doi.org/10.35760/jff.2024.v2i1.9699

Reubun, Y. T. A. (2021). Penghambatan Enzim Asetilkolinesterase Pada Penyakit Alzheimer Dari Ekstrak Etanol Daun Kelor (Moringa oleifera Lam.). Jurnal Farmasi Indonesia, 18(1), 64–73. https://doi.org/10.31001/jfi.v18i1.1105

Sausan, S., Fitriana, M., Abdillah, L. K., Lisi, F. H., Indriani, Z. I., Hidayat, L. H., & Hasina, R. (2023). Uji Aktivitas Antidepresan Ramuan Buah Adas (Foeniculum vulgare Mill.) Pada Mencit Jantan (Mus musculus) Dengan Metode Tail Suspension Test (TST). Unram Medical Journal, 12(2), 157–161. https://doi.org/10.29303/jk.v12i2.4390

Sirkadian, S. (2021). Dewi et al.;Perbandingan Aktivitas …..Pharmacoscript Volume 4 No. 1, Februari 2021. 4(1), 1–9.

Suryawijaya, N., Sam, C. I. L., & Gelgel, A. M. (2019). Gambaran Pengetahuan dan Perilaku Masyarakat Tentang Epilepsi di Kecamatan Kewapante, Kabupaten Sikka. Callosum Neurology, 2(3), 90–97. https://doi.org/10.29342/cnj.v2i3.73

Susanto, L. R. D., Nuryanti, A., & Wahyudi, I. A. (2013). Efek Minyak Atsiri Daun Kemangi (Ocimum Basilicum L.) Sebagai Agen Penghambat Pembentukan Biofilm Streptococcus Mutans. Idj, 2(1), 38–44.

Torres-Pasillas, G., Chi-Castañeda, D., Carrillo-Castilla, P., Marín, G., Hernández-Aguilar, M. E., Aranda-Abreu, G. E., Manzo, J., & García, L. I. (2023). Olfactory Dysfunction in Parkinson’s Disease, Its Functional and Neuroanatomical Correlates. NeuroSci, 4(2), 134–151. https://doi.org/10.3390/neurosci4020013

Uddin, M. J., & Zidorn, C. (2020). Traditional Herbal Medicines Against CNS Disorders from Bangladesh. In Natural Products and Bioprospecting (Vol. 10, Issue 6). Springer Singapore. https://doi.org/10.1007/s13659-020-00269-7

Yuliani, S., Bachri, M. S., Sofia, V., Widyaningsih, W., Muttaqien, D. A., Putri, G. R., Selvia, N., Rahmadita, S., & Rahmita, I. D. (2022). Aktivitas Ekstrak Rimpang Kunyit (Curcuma longa L) pada Mencit Parkinson yang Diinduksi Haloperidol. Jurnal Sain Veteriner, 40(3), 329. https://doi.org/10.22146/jsv.71871

Yulianita, Y., Effendi, E. M., & Firdayani, E. M. (2019). Sedative Effect of Citronella (Cymbopogon nardus (L.) Rendle) Towards Male Mice (Mus musculus). Indonesian Journal of Pharmaceutical Science and Technology Journal Homepage, 1(1), 16–23. http://jurnal.unpad.ac.id/ijpst/

Published
2025-04-16
How to Cite
Nasution, M. A., Gultom, N., & Silitonga, M. (2025). Literatur Review: Kajian Tanaman Obat Untuk Mengatasi Penyakit Sistem Saraf Pusat di Indonesia. Symbiotic: Journal of Biological Education and Science, 6(1), 32-44. https://doi.org/10.32939/symbiotic.v6i1.167